Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB
In recent months, the novel coronavirus disease 2019 (COVID-19) pandemic has become a major public health crisis with takeover more than 1 million lives worldwide. The long-lasting existence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not yet been reported. Herein, we report...
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doaj-8ece37f7a0274aa893d3bd961bcbed902021-10-03T07:42:37ZengDe GruyterOpen Medicine2391-54632021-05-0116174975310.1515/med-2021-0283Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHBLi Wenyuan0Huang Beibei1Shen Qiang2Jiang Shouwei3Jin Kun4Ning Ling5Liu Lei6Li Lei7Department of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ChinaIn recent months, the novel coronavirus disease 2019 (COVID-19) pandemic has become a major public health crisis with takeover more than 1 million lives worldwide. The long-lasting existence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not yet been reported. Herein, we report a case of SARS-CoV-2 infection with intermittent viral polymerase chain reaction (PCR)-positive for >4 months after clinical rehabilitation. A 35-year-old male was diagnosed with COVID-19 pneumonia with fever but without other specific symptoms. The treatment with lopinavir-ritonavir, oxygen inhalation, and other symptomatic supportive treatment facilitated recovery, and the patient was discharged. However, his viral PCR test was continually positive in oropharyngeal swabs for >4 months after that. At the end of June 2020, he was still under quarantine and observation. The contribution of current antivirus therapy might be limited. The prognosis of COVID-19 patients might be irrelevant to the virus status. Thus, further investigation to evaluate the contagiousness of convalescent patients and the mechanism underlying the persistent existence of SARS-CoV-2 after recovery is essential. A new strategy of disease control, especially extending the follow-up period for recovered COVID-19 patients, is necessary to adapt to the current situation of pandemic.https://doi.org/10.1515/med-2021-0283covid-19sars-cov-2convalescencecoronaviruscase report |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Wenyuan Huang Beibei Shen Qiang Jiang Shouwei Jin Kun Ning Ling Liu Lei Li Lei |
spellingShingle |
Li Wenyuan Huang Beibei Shen Qiang Jiang Shouwei Jin Kun Ning Ling Liu Lei Li Lei Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB Open Medicine covid-19 sars-cov-2 convalescence coronavirus case report |
author_facet |
Li Wenyuan Huang Beibei Shen Qiang Jiang Shouwei Jin Kun Ning Ling Liu Lei Li Lei |
author_sort |
Li Wenyuan |
title |
Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB |
title_short |
Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB |
title_full |
Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB |
title_fullStr |
Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB |
title_full_unstemmed |
Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB |
title_sort |
persistent sars-cov-2-positive over 4 months in a covid-19 patient with chb |
publisher |
De Gruyter |
series |
Open Medicine |
issn |
2391-5463 |
publishDate |
2021-05-01 |
description |
In recent months, the novel coronavirus disease 2019 (COVID-19) pandemic has become a major public health crisis with takeover more than 1 million lives worldwide. The long-lasting existence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not yet been reported. Herein, we report a case of SARS-CoV-2 infection with intermittent viral polymerase chain reaction (PCR)-positive for >4 months after clinical rehabilitation. A 35-year-old male was diagnosed with COVID-19 pneumonia with fever but without other specific symptoms. The treatment with lopinavir-ritonavir, oxygen inhalation, and other symptomatic supportive treatment facilitated recovery, and the patient was discharged. However, his viral PCR test was continually positive in oropharyngeal swabs for >4 months after that. At the end of June 2020, he was still under quarantine and observation. The contribution of current antivirus therapy might be limited. The prognosis of COVID-19 patients might be irrelevant to the virus status. Thus, further investigation to evaluate the contagiousness of convalescent patients and the mechanism underlying the persistent existence of SARS-CoV-2 after recovery is essential. A new strategy of disease control, especially extending the follow-up period for recovered COVID-19 patients, is necessary to adapt to the current situation of pandemic. |
topic |
covid-19 sars-cov-2 convalescence coronavirus case report |
url |
https://doi.org/10.1515/med-2021-0283 |
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