Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge

Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge

Abstract Background Cilomilast is a phosphodiesterase 4 (PDE4) inhibitor for treating inflammatory lung diseases. This agent has a narrow therapeutic index with significant adverse effects on the nervous system. This study was conducted to entrap cilomilast into PEGylated phosphatidylcholine-rich ni...

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Bibliographic Details
Main Authors: Fu-Chao Liu, Huang-Ping Yu, Cheng-Yu Lin, Ahmed O. Elzoghby, Tsong-Long Hwang, Jia-You Fang
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Nanobiotechnology
Subjects:
Cilomilast
Phosphatiosomes
Nanovesicle
Acute lung injury
Surface charge
Online Access:http://link.springer.com/article/10.1186/s12951-018-0364-z

Internet

http://link.springer.com/article/10.1186/s12951-018-0364-z

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