Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.

Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.

Methylated DNA immunoprecipitation followed by high-throughput sequencing (MeDIP-seq) has the potential to identify changes in DNA methylation important in cancer development. In order to understand the role of epigenetic modulation in the development of acute myeloid leukemia (AML) we have applied...

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Bibliographic Details
Main Authors: Marwa H Saied, Jacek Marzec, Sabah Khalid, Paul Smith, Thomas A Down, Vardhman K Rakyan, Gael Molloy, Manoj Raghavan, Silvana Debernardi, Bryan D Young
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3315563?pdf=render

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http://europepmc.org/articles/PMC3315563?pdf=render

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