Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance, obesity, hyperlipidemia, and hypertension. Since the obesity figures and related comorbidities are increasing, NAFLD has turned into a...
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doaj-8f7180011b224a00b35059de671c04892020-11-24T21:07:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-10-011610251682519810.3390/ijms161025168ijms161025168Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver DiseaseMaria Catalina Hernandez-Rodas0Rodrigo Valenzuela1Luis A. Videla2Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, ChileDepartment of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, ChileMolecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8380453, ChileNon-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance, obesity, hyperlipidemia, and hypertension. Since the obesity figures and related comorbidities are increasing, NAFLD has turned into a liver problem that has become progressively more common. Currently, there is no effective drug therapy for NAFLD; therefore, interventions in lifestyles remain the first line of treatment. Bearing in mind that adherence rates to this type of treatment are poor, great efforts are currently focused on finding novel therapeutic agents for the prevention in the development of hepatic steatosis and its progression to nonalcoholic steatohepatitis and cirrhosis. This review presents a compilation of the scientific evidence found in the last years showing the results of interventions in lifestyle, diet, and behavioral therapies and research results in human, animal and cell models. Possible therapeutic agents ranging from supplementation with vitamins, amino acids, prebiotics, probiotics, symbiotics, polyunsaturated fatty acids and polyphenols to interventions with medicinal plants are analyzed.http://www.mdpi.com/1422-0067/16/10/25168NAFLDlifestyledietexercisevitaminsamino acidsprebioticspolyunsaturated fatty acidspolyphenolsmedicinal plants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Catalina Hernandez-Rodas Rodrigo Valenzuela Luis A. Videla |
spellingShingle |
Maria Catalina Hernandez-Rodas Rodrigo Valenzuela Luis A. Videla Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease International Journal of Molecular Sciences NAFLD lifestyle diet exercise vitamins amino acids prebiotics polyunsaturated fatty acids polyphenols medicinal plants |
author_facet |
Maria Catalina Hernandez-Rodas Rodrigo Valenzuela Luis A. Videla |
author_sort |
Maria Catalina Hernandez-Rodas |
title |
Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease |
title_short |
Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease |
title_full |
Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease |
title_fullStr |
Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease |
title_full_unstemmed |
Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease |
title_sort |
relevant aspects of nutritional and dietary interventions in non-alcoholic fatty liver disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-10-01 |
description |
Non-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance, obesity, hyperlipidemia, and hypertension. Since the obesity figures and related comorbidities are increasing, NAFLD has turned into a liver problem that has become progressively more common. Currently, there is no effective drug therapy for NAFLD; therefore, interventions in lifestyles remain the first line of treatment. Bearing in mind that adherence rates to this type of treatment are poor, great efforts are currently focused on finding novel therapeutic agents for the prevention in the development of hepatic steatosis and its progression to nonalcoholic steatohepatitis and cirrhosis. This review presents a compilation of the scientific evidence found in the last years showing the results of interventions in lifestyle, diet, and behavioral therapies and research results in human, animal and cell models. Possible therapeutic agents ranging from supplementation with vitamins, amino acids, prebiotics, probiotics, symbiotics, polyunsaturated fatty acids and polyphenols to interventions with medicinal plants are analyzed. |
topic |
NAFLD lifestyle diet exercise vitamins amino acids prebiotics polyunsaturated fatty acids polyphenols medicinal plants |
url |
http://www.mdpi.com/1422-0067/16/10/25168 |
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