Neuroprotective Properties of Linagliptin: Focus on Biochemical Mechanisms in Cerebral Ischemia, Vascular Dysfunction and Certain Neurodegenerative Diseases

Neuroprotective Properties of Linagliptin: Focus on Biochemical Mechanisms in Cerebral Ischemia, Vascular Dysfunction and Certain Neurodegenerative Diseases

Linagliptin is a representative of dipeptidyl peptidase 4 (DPP-4) inhibitors which are registered and used effectively in a treatment of diabetes mellitus type 2. They increase the levels of active forms of endogenous incretins such as GLP-1 and GIP by inhibiting their enzymatic decomposition. Scien...

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Bibliographic Details
Main Authors: Michał Wiciński, Karol Górski, Maciej Walczak, Eryk Wódkiewicz, Maciej Słupski, Katarzyna Pawlak-Osińska, Bartosz Malinowski
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
linagliptin
inflammation
pathways
neurodegeneration
pharmacology
Online Access:https://www.mdpi.com/1422-0067/20/16/4052

Internet

https://www.mdpi.com/1422-0067/20/16/4052

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