Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center
IntroductionIn acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life qua...
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doaj-8fcf6f69192b4be9b7b3534a983d9af72021-03-16T15:39:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-03-011210.3389/fendo.2021.642131642131Complications and Comorbidities of Acromegaly—Retrospective Study in Polish CenterMałgorzata Rolla0Aleksandra Jawiarczyk-Przybyłowska1Jowita Halupczok-Żyła2Marcin Kałużny3Bogumil M. Konopka4Izabela Błoniecka5Grzegorz Zieliński6Marek Bolanowski7Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, University Clinical Hospital, Wrocław, PolandDepartment of Neurosurgery, Military Institute of Medicine, Warsaw, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandIntroductionIn acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life quality and premature mortality. The aim of our study was to assess the frequency of acromegaly complications and to evaluate diagnostic methods performed toward recognition of them.Materials and MethodsIt was a retrospective study and we analyzed data of 179 patients hospitalized in the Department of Endocrinology, Diabetes and Isotope Therapy in Wroclaw Medical University (Poland) in 1976 to 2018 to create a database for statistical analysis.ResultsThe study group comprised of 119 women (66%) and 60 men (34%). The median age of acromegaly diagnosis was 50.5 years old for women (age range 20–78) and 46 for men (range 24–76). Metabolic disorders (hyperlipidemia, diabetes, and prediabetes) were the most frequently diagnosed complications in our study, followed by cardiovascular diseases and endocrine disorders (goiter, pituitary insufficiency, osteoporosis). BP measurement, ECG, lipid profile, fasting glucose or OGTT were performed the most often, while colonoscopy and echocardiogram were the least frequent.ConclusionsIn our population we observed female predominance. We revealed a decrease in the number of patients with active acromegaly and an increase in the number of well-controlled patients. More than 50% of patients demonstrated a coexistence of cardiac, metabolic and endocrine disturbances and only 5% of patients did not suffer from any disease from those main groups.https://www.frontiersin.org/articles/10.3389/fendo.2021.642131/fullacromegalycomplicationcomorbiditypituitary adenomaIGF-IGH |
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language |
English |
format |
Article |
sources |
DOAJ |
author |
Małgorzata Rolla Aleksandra Jawiarczyk-Przybyłowska Jowita Halupczok-Żyła Marcin Kałużny Bogumil M. Konopka Izabela Błoniecka Grzegorz Zieliński Marek Bolanowski |
spellingShingle |
Małgorzata Rolla Aleksandra Jawiarczyk-Przybyłowska Jowita Halupczok-Żyła Marcin Kałużny Bogumil M. Konopka Izabela Błoniecka Grzegorz Zieliński Marek Bolanowski Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center Frontiers in Endocrinology acromegaly complication comorbidity pituitary adenoma IGF-I GH |
author_facet |
Małgorzata Rolla Aleksandra Jawiarczyk-Przybyłowska Jowita Halupczok-Żyła Marcin Kałużny Bogumil M. Konopka Izabela Błoniecka Grzegorz Zieliński Marek Bolanowski |
author_sort |
Małgorzata Rolla |
title |
Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center |
title_short |
Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center |
title_full |
Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center |
title_fullStr |
Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center |
title_full_unstemmed |
Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center |
title_sort |
complications and comorbidities of acromegaly—retrospective study in polish center |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2021-03-01 |
description |
IntroductionIn acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life quality and premature mortality. The aim of our study was to assess the frequency of acromegaly complications and to evaluate diagnostic methods performed toward recognition of them.Materials and MethodsIt was a retrospective study and we analyzed data of 179 patients hospitalized in the Department of Endocrinology, Diabetes and Isotope Therapy in Wroclaw Medical University (Poland) in 1976 to 2018 to create a database for statistical analysis.ResultsThe study group comprised of 119 women (66%) and 60 men (34%). The median age of acromegaly diagnosis was 50.5 years old for women (age range 20–78) and 46 for men (range 24–76). Metabolic disorders (hyperlipidemia, diabetes, and prediabetes) were the most frequently diagnosed complications in our study, followed by cardiovascular diseases and endocrine disorders (goiter, pituitary insufficiency, osteoporosis). BP measurement, ECG, lipid profile, fasting glucose or OGTT were performed the most often, while colonoscopy and echocardiogram were the least frequent.ConclusionsIn our population we observed female predominance. We revealed a decrease in the number of patients with active acromegaly and an increase in the number of well-controlled patients. More than 50% of patients demonstrated a coexistence of cardiac, metabolic and endocrine disturbances and only 5% of patients did not suffer from any disease from those main groups. |
topic |
acromegaly complication comorbidity pituitary adenoma IGF-I GH |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2021.642131/full |
work_keys_str_mv |
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