Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center

IntroductionIn acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life qua...

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Main Authors: Małgorzata Rolla, Aleksandra Jawiarczyk-Przybyłowska, Jowita Halupczok-Żyła, Marcin Kałużny, Bogumil M. Konopka, Izabela Błoniecka, Grzegorz Zieliński, Marek Bolanowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Endocrinology
Subjects:
GH
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.642131/full
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spelling doaj-8fcf6f69192b4be9b7b3534a983d9af72021-03-16T15:39:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-03-011210.3389/fendo.2021.642131642131Complications and Comorbidities of Acromegaly—Retrospective Study in Polish CenterMałgorzata Rolla0Aleksandra Jawiarczyk-Przybyłowska1Jowita Halupczok-Żyła2Marcin Kałużny3Bogumil M. Konopka4Izabela Błoniecka5Grzegorz Zieliński6Marek Bolanowski7Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, University Clinical Hospital, Wrocław, PolandDepartment of Neurosurgery, Military Institute of Medicine, Warsaw, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, PolandIntroductionIn acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life quality and premature mortality. The aim of our study was to assess the frequency of acromegaly complications and to evaluate diagnostic methods performed toward recognition of them.Materials and MethodsIt was a retrospective study and we analyzed data of 179 patients hospitalized in the Department of Endocrinology, Diabetes and Isotope Therapy in Wroclaw Medical University (Poland) in 1976 to 2018 to create a database for statistical analysis.ResultsThe study group comprised of 119 women (66%) and 60 men (34%). The median age of acromegaly diagnosis was 50.5 years old for women (age range 20–78) and 46 for men (range 24–76). Metabolic disorders (hyperlipidemia, diabetes, and prediabetes) were the most frequently diagnosed complications in our study, followed by cardiovascular diseases and endocrine disorders (goiter, pituitary insufficiency, osteoporosis). BP measurement, ECG, lipid profile, fasting glucose or OGTT were performed the most often, while colonoscopy and echocardiogram were the least frequent.ConclusionsIn our population we observed female predominance. We revealed a decrease in the number of patients with active acromegaly and an increase in the number of well-controlled patients. More than 50% of patients demonstrated a coexistence of cardiac, metabolic and endocrine disturbances and only 5% of patients did not suffer from any disease from those main groups.https://www.frontiersin.org/articles/10.3389/fendo.2021.642131/fullacromegalycomplicationcomorbiditypituitary adenomaIGF-IGH
collection DOAJ
language English
format Article
sources DOAJ
author Małgorzata Rolla
Aleksandra Jawiarczyk-Przybyłowska
Jowita Halupczok-Żyła
Marcin Kałużny
Bogumil M. Konopka
Izabela Błoniecka
Grzegorz Zieliński
Marek Bolanowski
spellingShingle Małgorzata Rolla
Aleksandra Jawiarczyk-Przybyłowska
Jowita Halupczok-Żyła
Marcin Kałużny
Bogumil M. Konopka
Izabela Błoniecka
Grzegorz Zieliński
Marek Bolanowski
Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center
Frontiers in Endocrinology
acromegaly
complication
comorbidity
pituitary adenoma
IGF-I
GH
author_facet Małgorzata Rolla
Aleksandra Jawiarczyk-Przybyłowska
Jowita Halupczok-Żyła
Marcin Kałużny
Bogumil M. Konopka
Izabela Błoniecka
Grzegorz Zieliński
Marek Bolanowski
author_sort Małgorzata Rolla
title Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center
title_short Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center
title_full Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center
title_fullStr Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center
title_full_unstemmed Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center
title_sort complications and comorbidities of acromegaly—retrospective study in polish center
publisher Frontiers Media S.A.
series Frontiers in Endocrinology
issn 1664-2392
publishDate 2021-03-01
description IntroductionIn acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life quality and premature mortality. The aim of our study was to assess the frequency of acromegaly complications and to evaluate diagnostic methods performed toward recognition of them.Materials and MethodsIt was a retrospective study and we analyzed data of 179 patients hospitalized in the Department of Endocrinology, Diabetes and Isotope Therapy in Wroclaw Medical University (Poland) in 1976 to 2018 to create a database for statistical analysis.ResultsThe study group comprised of 119 women (66%) and 60 men (34%). The median age of acromegaly diagnosis was 50.5 years old for women (age range 20–78) and 46 for men (range 24–76). Metabolic disorders (hyperlipidemia, diabetes, and prediabetes) were the most frequently diagnosed complications in our study, followed by cardiovascular diseases and endocrine disorders (goiter, pituitary insufficiency, osteoporosis). BP measurement, ECG, lipid profile, fasting glucose or OGTT were performed the most often, while colonoscopy and echocardiogram were the least frequent.ConclusionsIn our population we observed female predominance. We revealed a decrease in the number of patients with active acromegaly and an increase in the number of well-controlled patients. More than 50% of patients demonstrated a coexistence of cardiac, metabolic and endocrine disturbances and only 5% of patients did not suffer from any disease from those main groups.
topic acromegaly
complication
comorbidity
pituitary adenoma
IGF-I
GH
url https://www.frontiersin.org/articles/10.3389/fendo.2021.642131/full
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