Regulation of cardiac excitation-contraction coupling by sorcin, a novel modulator of ryanodine receptors

Activation of Ca2+ release channels/ryanodine receptors (RyR) by the inward Ca2+ current (I Ca) gives rise to Ca2+-induced Ca2+ release (CICR), the amplifying Ca2+ signaling mechanism that triggers contraction of the heart. CICR, in theory, is a high-gain, self-regenerating process, but an unidentif...

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Bibliographic Details
Main Authors: EMILY F FARRELL, ANAID ANTARAMIAN, NANCY BENKUSKY, XINSHENG ZHU, ANGÉLICA RUEDA, ANA M GÓMEZ, HÉCTOR H VALDIVIA
Format: Article
Language:English
Published: BMC 2004-01-01
Series:Biological Research
Subjects:
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400015

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