The frequency of neoantigens per somatic mutation rather than overall mutational load or number of predicted neoantigens per se is a prognostic factor in ovarian clear cell carcinoma

The frequency of neoantigens per somatic mutation rather than overall mutational load or number of predicted neoantigens per se is a prognostic factor in ovarian clear cell carcinoma

Neoantigens derived from tumor-specific somatic mutations are excellent targets for anti-tumor immune responses. In ovarian clear cell carcinoma (OCCC), checkpoint blockade yields durable responses in a subset of patients. To approach the question of why only some patients respond, we first investig...

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Bibliographic Details
Main Authors: Hirokazu Matsushita, Kosei Hasegawa, Katsutoshi Oda, Shogo Yamamoto, Akira Nishijima, Yuichi Imai, Kayo Asada, Yuji Ikeda, Takahiro Karasaki, Keiichi Fujiwara, Hiroyuki Aburatani, Kazuhiro Kakimi
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:OncoImmunology
Subjects:
immune signature
missense mutation
neoantigen
neoantigen frequency
ovarian clear cell carcinoma
prognostic factor
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1338996

Internet

http://dx.doi.org/10.1080/2162402X.2017.1338996

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