GTPase activity plays a key role in the pathobiology of LRRK2.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, including functional Roc GTPase and protein kin...
Main Authors: | Yulan Xiong, Candice E Coombes, Austin Kilaru, Xiaojie Li, Aaron D Gitler, William J Bowers, Valina L Dawson, Ted M Dawson, Darren J Moore |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-04-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2851569?pdf=render |
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