Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.

Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.

CCR2 is considered a proinflammatory mediator in many inflammatory diseases such as rheumatoid arthritis. However, mice lacking CCR2 develop exacerbated collagen-induced arthritis. To explore the underlying mechanism, we investigated whether autoimmune-associated Th17 cells were involved in the path...

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Bibliographic Details
Main Authors: Rishi R Rampersad, Teresa K Tarrant, Christopher T Vallanat, Tatiana Quintero-Matthews, Michael F Weeks, Denise A Esserman, Jennifer Clark, Franco Di Padova, Dhavalkumar D Patel, Alan M Fong, Peng Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3186765?pdf=render

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