Early-onset behavioral and neurochemical deficits in the genetic mouse model of phenylketonuria.

Early-onset behavioral and neurochemical deficits in the genetic mouse model of phenylketonuria.

Phenylketonuria (PKU) is one of the most common human inborn errors of metabolism, caused by phenylalanine hydroxylase deficiency, leading to high phenylalanine and low tyrosine levels in blood and brain causing profound cognitive disability, if untreated. Since 1960, population is screened for hype...

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Bibliographic Details
Main Authors: Elena Fiori, Diego Oddi, Rossella Ventura, Marco Colamartino, Alessandro Valzania, Francesca Romana D'Amato, Vibeke Bruinenberg, Eddy van der Zee, Stefano Puglisi-Allegra, Tiziana Pascucci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5574541?pdf=render

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http://europepmc.org/articles/PMC5574541?pdf=render

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