Astrocytic Calcium Dynamics Along the Pain Pathway
Astrocytes, once thought to be passive cells merely filling the space between neurons in the nervous system, are receiving attention as active modulators of the brain and spinal cord physiology by providing nutrients, maintaining homeostasis, and modulating synaptic transmission. Accumulating eviden...
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doaj-909ed57f75634d2fa2d80d3b7d2f1a742020-11-25T01:53:45ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-10-011410.3389/fncel.2020.594216594216Astrocytic Calcium Dynamics Along the Pain PathwayJeiwon Cho0Yeowool Huh1Yeowool Huh2Brain and Cognitive Science, Scranton College, Ewha Womans University, Seoul, South KoreaDepartment of Medical Science, College of Medicine, Catholic Kwandong University, Incheon, South KoreaTranslational Brain Research Center, Catholic Kwandong University, International St. Mary’s Hospital, Incheon, South KoreaAstrocytes, once thought to be passive cells merely filling the space between neurons in the nervous system, are receiving attention as active modulators of the brain and spinal cord physiology by providing nutrients, maintaining homeostasis, and modulating synaptic transmission. Accumulating evidence indicates that astrocytes are critically involved in chronic pain regulation. Injury induces astrocytes to become reactive, and recent studies suggest that reactive astrocytes can have either neuroprotective or neurodegenerative effects. While the exact mechanisms underlying the transition from resting astrocytes to reactive astrocytes remain unknown, astrocytic calcium increase, coordinated by inflammatory molecules, has been suggested to trigger this transition. In this mini review article, we will discuss the roles of astrocytic calcium, channels contributing to calcium dynamics in astrocytes, astrocyte activations along the pain pathway, and possible relationships between astrocytic calcium dynamics and chronic pain.https://www.frontiersin.org/article/10.3389/fncel.2020.594216/fullastrocytecalciumcalcium channelspain pathwaychronic painneuropathic pain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeiwon Cho Yeowool Huh Yeowool Huh |
spellingShingle |
Jeiwon Cho Yeowool Huh Yeowool Huh Astrocytic Calcium Dynamics Along the Pain Pathway Frontiers in Cellular Neuroscience astrocyte calcium calcium channels pain pathway chronic pain neuropathic pain |
author_facet |
Jeiwon Cho Yeowool Huh Yeowool Huh |
author_sort |
Jeiwon Cho |
title |
Astrocytic Calcium Dynamics Along the Pain Pathway |
title_short |
Astrocytic Calcium Dynamics Along the Pain Pathway |
title_full |
Astrocytic Calcium Dynamics Along the Pain Pathway |
title_fullStr |
Astrocytic Calcium Dynamics Along the Pain Pathway |
title_full_unstemmed |
Astrocytic Calcium Dynamics Along the Pain Pathway |
title_sort |
astrocytic calcium dynamics along the pain pathway |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2020-10-01 |
description |
Astrocytes, once thought to be passive cells merely filling the space between neurons in the nervous system, are receiving attention as active modulators of the brain and spinal cord physiology by providing nutrients, maintaining homeostasis, and modulating synaptic transmission. Accumulating evidence indicates that astrocytes are critically involved in chronic pain regulation. Injury induces astrocytes to become reactive, and recent studies suggest that reactive astrocytes can have either neuroprotective or neurodegenerative effects. While the exact mechanisms underlying the transition from resting astrocytes to reactive astrocytes remain unknown, astrocytic calcium increase, coordinated by inflammatory molecules, has been suggested to trigger this transition. In this mini review article, we will discuss the roles of astrocytic calcium, channels contributing to calcium dynamics in astrocytes, astrocyte activations along the pain pathway, and possible relationships between astrocytic calcium dynamics and chronic pain. |
topic |
astrocyte calcium calcium channels pain pathway chronic pain neuropathic pain |
url |
https://www.frontiersin.org/article/10.3389/fncel.2020.594216/full |
work_keys_str_mv |
AT jeiwoncho astrocyticcalciumdynamicsalongthepainpathway AT yeowoolhuh astrocyticcalciumdynamicsalongthepainpathway AT yeowoolhuh astrocyticcalciumdynamicsalongthepainpathway |
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