Arenavirus Evasion of Host Anti-Viral Responses
The innate response to infection by an Old World arenavirus is initiated and mediated by extracellular and intracellular receptors, and effector molecules. In response, the invading virus has evolved to inhibit these responses and create the best environment possible for replication and spread. Here...
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MDPI AG
2012-10-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/4/10/2182 |
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doaj-90a1439fcbb240fdaa62d88ce6fce7812020-11-24T22:56:07ZengMDPI AGViruses1999-49152012-10-014102182219610.3390/v4102182Arenavirus Evasion of Host Anti-Viral ResponsesMelissa HayesMaria SalvatoThe innate response to infection by an Old World arenavirus is initiated and mediated by extracellular and intracellular receptors, and effector molecules. In response, the invading virus has evolved to inhibit these responses and create the best environment possible for replication and spread. Here, we will discuss both the host’s response to infection with data from human infection and lessons learned from animal models, as well as the multitude of ways the virus combats the resulting immune response. Finally, we will highlight recent work identifying TLR2 as an innate sensor for arenaviruses and how the TLR2-dependent response differs depending on the pathogenicity of the strain.http://www.mdpi.com/1999-4915/4/10/2182arenavirusinnate immune responseimmune evasionTLR2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Melissa Hayes Maria Salvato |
| spellingShingle |
Melissa Hayes Maria Salvato Arenavirus Evasion of Host Anti-Viral Responses Viruses arenavirus innate immune response immune evasion TLR2 |
| author_facet |
Melissa Hayes Maria Salvato |
| author_sort |
Melissa Hayes |
| title |
Arenavirus Evasion of Host Anti-Viral Responses |
| title_short |
Arenavirus Evasion of Host Anti-Viral Responses |
| title_full |
Arenavirus Evasion of Host Anti-Viral Responses |
| title_fullStr |
Arenavirus Evasion of Host Anti-Viral Responses |
| title_full_unstemmed |
Arenavirus Evasion of Host Anti-Viral Responses |
| title_sort |
arenavirus evasion of host anti-viral responses |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2012-10-01 |
| description |
The innate response to infection by an Old World arenavirus is initiated and mediated by extracellular and intracellular receptors, and effector molecules. In response, the invading virus has evolved to inhibit these responses and create the best environment possible for replication and spread. Here, we will discuss both the host’s response to infection with data from human infection and lessons learned from animal models, as well as the multitude of ways the virus combats the resulting immune response. Finally, we will highlight recent work identifying TLR2 as an innate sensor for arenaviruses and how the TLR2-dependent response differs depending on the pathogenicity of the strain. |
| topic |
arenavirus innate immune response immune evasion TLR2 |
| url |
http://www.mdpi.com/1999-4915/4/10/2182 |
| work_keys_str_mv |
AT melissahayes arenavirusevasionofhostantiviralresponses AT mariasalvato arenavirusevasionofhostantiviralresponses |
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1725654874554630144 |