BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis

BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis

Abstract The breast cancer susceptibility gene 1 (BRCA1) is a major tumor suppressor gene and is most frequently mutated in hereditary breast cancer. BRCA1 plays a critical role in many biological processes, especially maintaining genomic stability in the nucleus, yet its role in the cytoplasm remai...

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Bibliographic Details
Main Authors: Qiang Chen, Josh Haipeng Lei, Jiaolin Bao, Haitao Wang, Wenhui Hao, Licen Li, Cheng Peng, Takaaki Masuda, Kai Miao, Jun Xu, Xiaoling Xu, Chu‐Xia Deng
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Advanced Science
Subjects:
ATM‐AMPK‐DRP1
BRCA1
inflammasomes
mitochondrial dynamics
mitophagy
Online Access:https://doi.org/10.1002/advs.201903616

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