The Inhibition of Stat5 by a Peptide Aptamer Ligand Specific for the DNA Binding Domain Prevents Target Gene Transactivation and the Growth of Breast and Prostate Tumor Cells

The Inhibition of Stat5 by a Peptide Aptamer Ligand Specific for the DNA Binding Domain Prevents Target Gene Transactivation and the Growth of Breast and Prostate Tumor Cells

The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was initially observed in leukemias, but subsequently al...

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Bibliographic Details
Main Authors: Vida Vafaizadeh, Bernd Groner, Boris Brill, Natalia Delis, Richard Moriggl, Corina Borghouts, Christian Brendel, Axel Weber
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Pharmaceuticals
Subjects:
peptide aptamer (PA)
signal transducer and activator of transcription 5 (Stat5)
RNA interference (RNAi)
yeast-two-hybrid (Y2H)
protein transduction
prostate and breast cancer cell lines
inhibition of DNA-binding
Online Access:http://www.mdpi.com/1424-8247/6/8/960

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http://www.mdpi.com/1424-8247/6/8/960

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