High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Abstract Background Liver is the crucial organ as a hub for metabolic reactions. p16(INK4a) is a well-established cyclin-dependent kinase (CDK) inhibitor that plays important role in the molecular pathways of senescence, which lead to irreversible cell cycle arrest with secretion of proinflammatory...

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Bibliographic Details
Main Authors: Xiyuan Zhang, Guanying Bianca Xu, Dan Zhou, Yuan-Xiang Pan
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Genes & Nutrition
Subjects:
High-fat diet
p21(Cip1)
Fatty liver
Hepatic cellular senescence
Chromatin modification
Online Access:http://link.springer.com/article/10.1186/s12263-018-0595-5

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http://link.springer.com/article/10.1186/s12263-018-0595-5

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