The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.

The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.

Autophagy is a catabolic process that delivers cytoplasmic components to the lysosomes. Protein modification by ubiquitination is involved in this pathway: it regulates the stability of autophagy regulators such as BECLIN-1 and it also functions as a tag targeting specific substrates to autophagosom...

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Bibliographic Details
Main Authors: Anne-Claire Jacomin, Amandine Bescond, Emmanuelle Soleilhac, Benoît Gallet, Guy Schoehn, Marie-Odile Fauvarque, Emmanuel Taillebourg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4646453?pdf=render

Internet

http://europepmc.org/articles/PMC4646453?pdf=render

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