Proper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes

Proper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes

Background/Aims: Dysferlin plays a decisive role in calcium-dependent membrane repair in myocytes. Mutations in the encoding DYSF gene cause a number of myopathies, e.g. limb-girdle muscular dystrophy type 2B (LGMD2B). Besides skeletal muscle degenerative processes, dysferlin deficiency is also asso...

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Bibliographic Details
Main Authors: Lena Rubi, Vaibhavkumar S. Gawali, Helmut Kubista, Hannes Todt, Karlheinz Hilber, Xaver Koenig
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Dysferlin deficiency
Ventricular cardiomyocytes
Limb-girdle muscular dystrophy type 2B
L-type calcium channel
Mouse model
Voltage-dependent ion channels
Dilated cardiomyopathy
Online Access:http://www.karger.com/Article/FullText/430278

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http://www.karger.com/Article/FullText/430278

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