Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancers

Abstract Immune checkpoint therapy (ICT) can produce durable antitumor responses in various cancer types; however, the responses are not universal, and the predictive biomarkers are urgently needed. Growing evidence points to a link between epigenetic regulation and anti-tumor immunity, while clinic...

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Bibliographic Details
Main Authors: Peng Zhang, Yixuan Huang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Hematology & Oncology
Subjects:
Online Access:https://doi.org/10.1186/s13045-021-01050-0