Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets

Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets

Abstract Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integrins. Receptor ectodomain shedding is an elective mechanism which is mainly involved...

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Bibliographic Details
Main Authors: Ehteramolsadat Hosseini, Maryam Mohtashami, Mehran Ghasemzadeh
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Thrombosis Journal
Subjects:
αIIbβ3
Adhesion
Ectodomain shedding
GPIbα
GPVI
Microparticle
Online Access:http://link.springer.com/article/10.1186/s12959-019-0209-5

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http://link.springer.com/article/10.1186/s12959-019-0209-5

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