Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

Cell-to-cell transmission of TDP43 occurs in cell cultures and may contribute to pathological TDP43 propagation in FTLD-TDP. In this study, the authors demonstrate using mouse models that a single intracerebral injection of human brain-derived pathological TDP43 from FTLD-TDP cases initiates the pro...

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Bibliographic Details
Main Authors: Sílvia Porta, Yan Xu, Clark R. Restrepo, Linda K. Kwong, Bin Zhang, Hannah J. Brown, Edward B. Lee, John Q. Trojanowski, Virginia M.-Y. Lee
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06548-9

Internet

https://doi.org/10.1038/s41467-018-06548-9

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