Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease

Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease

Abstract Background Congenital heart disease (CHD) occurs in almost 1% of newborn children and is considered a multifactorial disorder. CHD may segregate in families due to significant contribution of genetic factors in the disease etiology. The aim of the study was to identify pathophysiological me...

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Bibliographic Details
Main Authors: Jose M. G. Izarzugaza, Sabrina G. Ellesøe, Canan Doganli, Natasja Spring Ehlers, Marlene D. Dalgaard, Enrique Audain, Gregor Dombrowsky, Karina Banasik, Alejandro Sifrim, Anna Wilsdon, Bernard Thienpont, Jeroen Breckpot, Marc Gewillig, Competence Network for Congenital Heart Defects, Germany, J. David Brook, Marc-Phillip Hitz, Lars A. Larsen, Søren Brunak
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Genome Medicine
Subjects:
Congenital heart disease
Genetics
Whole exome sequencing
Developmental biology
Systems biology
Calcium signaling
Online Access:http://link.springer.com/article/10.1186/s13073-020-00772-z

Internet

http://link.springer.com/article/10.1186/s13073-020-00772-z

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