Role of Brf1 interaction with ERα, and significance of its overexpression, in human breast cancer

Role of Brf1 interaction with ERα, and significance of its overexpression, in human breast cancer

TFIIB‐related factor 1 (Brf1) modulates the transcription of RNA Pol III genes (polymerase‐dependent genes). Upregulation of Pol III genes enhances tRNA and 5S RNA production and increases the translational capacity of cells to promote cell transformation and tumor development. However, the signific...

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Bibliographic Details
Main Authors: Zeng Fang, Yunfeng Yi, Ganggang Shi, Songqi Li, Songlin Chen, Ying Lin, Zhi Li, Zhimin He, Wen Li, Shuping Zhong
Format: Article
Language:English
Published: Wiley 2017-12-01
Series:Molecular Oncology
Subjects:
breast cancer
Brf1
ERα
Pol III genes
survival period
Online Access:https://doi.org/10.1002/1878-0261.12141

Internet

https://doi.org/10.1002/1878-0261.12141

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