Indolic Uremic Solutes Enhance Procoagulant Activity of Red Blood Cells through Phosphatidylserine Exposure and Microparticle Release

Indolic Uremic Solutes Enhance Procoagulant Activity of Red Blood Cells through Phosphatidylserine Exposure and Microparticle Release

Increased accumulation of indolic uremic solutes in the blood of uremic patients contributes to the risk of thrombotic events. Red blood cells (RBCs), the most abundant blood cells in circulation, may be a privileged target of these solutes. However, the effect of uremic solutes indoxyl sulfate (IS)...

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Bibliographic Details
Main Authors: Chunyan Gao, Shuting Ji, Weijun Dong, Yushan Qi, Wen Song, Debin Cui, Jialan Shi
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Toxins
Subjects:
indoxyl sulfate
indole-3-acetic acid
phosphatidylserine
microparticle
procoagulant
red blood cell
Online Access:http://www.mdpi.com/2072-6651/7/11/4390

Internet

http://www.mdpi.com/2072-6651/7/11/4390

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