A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative Radiotherapy
A case of mucinous adenocarcinoma arising on a long-standing anorectal fistula is described. A 60-year-old man with a long history of mucinous discharge, pain and perianal induration underwent a biopsy of the external opening of the fistula that showed a mucinous infiltrating adenocarcinoma. Due to...
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doaj-934b2438465247ecb5ce8accd2ba59f92020-11-25T00:08:15ZengKarger PublishersCase Reports in Gastroenterology1662-06312013-05-017221922310.1159/000351830351830A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative RadiotherapyRyo OhtaKoji SekikawaManabu GotoKazuhiro NaritaYasumasa TakahashiHironari IkedaMasataka OneyamaYudai HirataMikihiro NakayamaYohta ShimodaSyun SatoA case of mucinous adenocarcinoma arising on a long-standing anorectal fistula is described. A 60-year-old man with a long history of mucinous discharge, pain and perianal induration underwent a biopsy of the external opening of the fistula that showed a mucinous infiltrating adenocarcinoma. Due to the large size of the tumor and the fact that it had extended into the surrounding tissue, preoperative radiotherapy was performed. Radiotherapy was given with 40 Gy in 25 fractions for 5 weeks through posterior and bilateral portals. After radiotherapy the tumor was markedly shrunk and the serum level of carcinoembryonic antigen was also improved. Abdominoperineal resection was performed 8 weeks after the termination of radiotherapy. Histological examination of the resected specimen revealed that the invasion of the tumor remained within the sphincter muscle and that no cancer cells were present on the surgical margin. The histological effect of radiotherapy was judged as grade 1b. This treatment can result in downstaging and R0 resection, which also has a possibility to prevent local recurrence. This case suggests that preoperative radiotherapy may play an important role in the definitive treatment of locally advanced perianal mucinous adenocarcinoma.http://www.karger.com/Article/FullText/351830Perianal mucinous adenocarcinomaAnorectal fistulaPreoperative radiotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryo Ohta Koji Sekikawa Manabu Goto Kazuhiro Narita Yasumasa Takahashi Hironari Ikeda Masataka Oneyama Yudai Hirata Mikihiro Nakayama Yohta Shimoda Syun Sato |
spellingShingle |
Ryo Ohta Koji Sekikawa Manabu Goto Kazuhiro Narita Yasumasa Takahashi Hironari Ikeda Masataka Oneyama Yudai Hirata Mikihiro Nakayama Yohta Shimoda Syun Sato A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative Radiotherapy Case Reports in Gastroenterology Perianal mucinous adenocarcinoma Anorectal fistula Preoperative radiotherapy |
author_facet |
Ryo Ohta Koji Sekikawa Manabu Goto Kazuhiro Narita Yasumasa Takahashi Hironari Ikeda Masataka Oneyama Yudai Hirata Mikihiro Nakayama Yohta Shimoda Syun Sato |
author_sort |
Ryo Ohta |
title |
A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative Radiotherapy |
title_short |
A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative Radiotherapy |
title_full |
A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative Radiotherapy |
title_fullStr |
A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative Radiotherapy |
title_full_unstemmed |
A Case of Perianal Mucinous Adenocarcinoma Arising from an Anorectal Fistula Successfully Resected after Preoperative Radiotherapy |
title_sort |
case of perianal mucinous adenocarcinoma arising from an anorectal fistula successfully resected after preoperative radiotherapy |
publisher |
Karger Publishers |
series |
Case Reports in Gastroenterology |
issn |
1662-0631 |
publishDate |
2013-05-01 |
description |
A case of mucinous adenocarcinoma arising on a long-standing anorectal fistula is described. A 60-year-old man with a long history of mucinous discharge, pain and perianal induration underwent a biopsy of the external opening of the fistula that showed a mucinous infiltrating adenocarcinoma. Due to the large size of the tumor and the fact that it had extended into the surrounding tissue, preoperative radiotherapy was performed. Radiotherapy was given with 40 Gy in 25 fractions for 5 weeks through posterior and bilateral portals. After radiotherapy the tumor was markedly shrunk and the serum level of carcinoembryonic antigen was also improved. Abdominoperineal resection was performed 8 weeks after the termination of radiotherapy. Histological examination of the resected specimen revealed that the invasion of the tumor remained within the sphincter muscle and that no cancer cells were present on the surgical margin. The histological effect of radiotherapy was judged as grade 1b. This treatment can result in downstaging and R0 resection, which also has a possibility to prevent local recurrence. This case suggests that preoperative radiotherapy may play an important role in the definitive treatment of locally advanced perianal mucinous adenocarcinoma. |
topic |
Perianal mucinous adenocarcinoma Anorectal fistula Preoperative radiotherapy |
url |
http://www.karger.com/Article/FullText/351830 |
work_keys_str_mv |
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