Silver nanoparticles induced cytotoxicity in HT22 cells through autophagy and apoptosis via PI3K/AKT/mTOR signaling pathway

Silver nanoparticles induced cytotoxicity in HT22 cells through autophagy and apoptosis via PI3K/AKT/mTOR signaling pathway

With the widespread application and inevitable environmental exposure, silver nanoparticles (AgNPs) can be accumulated in various organs. More serious concerns are raised on the biological safety and potential toxicity of AgNPs in the central nervous system (CNS), especially in the hippocampus. This...

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Bibliographic Details
Main Authors: Xiaoru Chang, Xiujuan Wang, Jiangyan Li, Mengting Shang, Shuyan Niu, Wenli Zhang, Yunjing Li, Zuoyi Sun, Junying Gan, Wenhua Li, Meng Tang, Yuying Xue
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Silver nanoparticles
Neurotoxicity
ROS
Autophagy
Apoptosis
PI3K/AKT/mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320315335

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http://www.sciencedirect.com/science/article/pii/S0147651320315335

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