Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against <i>Candida albicans</i> and <i>Candida krusei</i>

Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against <i>Candida albicans</i> and <i>Candida krusei</i>

Systemic mycoses are one major cause of morbidity/mortality among immunocompromised/debilitated individuals. Studying the mechanism of action is a strategy to develop safer/potent antifungals, warning resistance emergence. The major goal of this study was to elucidate the mechanism of action of thre...

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Bibliographic Details
Main Authors: Fátima Cerqueira, Marta Maia, Carla Gabriel, Rui Medeiros, Sara Cravo, Ana Isabel Ribeiro, Daniela Dantas, Alice Maria Dias, Lucília Saraiva, Liliana Raimundo, Eugénia Pinto
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antibiotics
Subjects:
<i>Candida</i> sp.
antifungals
(<i>Z</i>)-5-amino-<i>N</i>’-aryl-1-methyl-1<i>H</i>-imidazole-4-carbohydrazonamides
mechanisms of action
reactive oxygen species
ergosterol
Online Access:https://www.mdpi.com/2079-6382/10/2/183

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https://www.mdpi.com/2079-6382/10/2/183

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