Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay

Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay

Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses. As for every other antiviral immune system, there is also evi...

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Bibliographic Details
Main Authors: Giuseppe Balistreri, Claudia Bognanni, Oliver Mühlemann
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Viruses
Subjects:
RNA quality control
gene expression
translation
RNA-protein interactions
Online Access:http://www.mdpi.com/1999-4915/9/1/24
Description
Summary:Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses. As for every other antiviral immune system, there is also evidence of viruses interfering with and modulating NMD to their own advantage. This review will discuss our current understanding of why and how NMD targets viral RNAs, and elaborate counter-defense strategies viruses utilize to escape NMD.
ISSN:1999-4915

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