CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
Neutrophils and macrophages are important constituents of the hepatic inflammatory infiltrate in non-alcoholic steatohepatitis. These innate immune cells express CD18, an adhesion molecule that facilitates leukocyte activation. In the context of fatty liver, activation of infiltrated leukocytes is b...
Main Authors: | Andrew A Pierce, Caroline C Duwaerts, Kevin Siao, Aras N Mattis, Amanda Goodsell, Jody L Baron, Jacquelyn J Maher |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5584926?pdf=render |
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