Goats without Prion Protein Display Enhanced Proinflammatory Pulmonary Signaling and Extracellular Matrix Remodeling upon Systemic Lipopolysaccharide Challenge

Goats without Prion Protein Display Enhanced Proinflammatory Pulmonary Signaling and Extracellular Matrix Remodeling upon Systemic Lipopolysaccharide Challenge

A naturally occurring mutation in the PRNP gene of Norwegian dairy goats terminates synthesis of the cellular prion protein (PrPC), rendering homozygous goats (PRNPTer/Ter) devoid of the protein. Although PrPC has been extensively studied, particularly in the central nervous system, the biological r...

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Bibliographic Details
Main Authors: Øyvind Salvesen, Malin R. Reiten, Jorke H. Kamstra, Maren K. Bakkebø, Arild Espenes, Michael A. Tranulis, Cecilie Ersdal
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
acute lung injury
cellular prion protein
systemic inflammation
lipopolysaccharide
innate immunity
RNA sequencing
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01722/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01722/full

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