Critical role of intracellular RyR1 calcium release channels in skeletal muscle function and disease

The skeletal muscle Ca2+ release channel, also known as ryanodine receptor type 1 (RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle contractile activation. RyR1 function is controlled by Cav1.1, a voltage gated Ca2+ channel that works mainly as a voltage...

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Bibliographic Details
Main Authors: Erick Omar Hernández-Ochoa, Stephen JP Pratt, Richard M Lovering, Martin F Schneider
Format: Article
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Physiology
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