Indoleamine 2, 3-Dioxygenase-Mediated Tryptophan Catabolism: A Leading Star or Supporting Act in the Tuberculosis and HIV Pas-de-Deux?

Indoleamine 2, 3-Dioxygenase-Mediated Tryptophan Catabolism: A Leading Star or Supporting Act in the Tuberculosis and HIV Pas-de-Deux?

Progression from latency to active Tuberculosis (TB) disease is mediated by incompletely understood host immune factors. The definitive characteristic of progressive human immunodeficiency virus (HIV) disease is a severe loss in number and function of T lymphocytes. Among the many possible mediators...

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Bibliographic Details
Main Authors: Clement Gascua Adu-Gyamfi, Dana Savulescu, Jaya Anna George, Melinda Shelley Suchard
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
IDO
latent TB
active TB
kynurenine/tryptophan ratio
nicotinamide
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00372/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00372/full

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