On Two-stage Seamless Adaptive Design in Clinical Trials

In recent years, the use of adaptive design methods in clinical research and development based on accrued data has become very popular because of its efficiency and flexibility in modifying trial and/or statistical procedures of ongoing clinical trials. One of the most commonly considered adaptive d...

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Bibliographic Details
Main Authors: Shein-Chung Chow, Yi-Hsuan Tu
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Journal of the Formosan Medical Association
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664609600097