Implementation of a pragmatic, stepped-wedge cluster randomized trial to evaluate impact of Botswana’s Xpert MTB/RIF diagnostic algorithm on TB diagnostic sensitivity and early antiretroviral therapy mortality

Implementation of a pragmatic, stepped-wedge cluster randomized trial to evaluate impact of Botswana’s Xpert MTB/RIF diagnostic algorithm on TB diagnostic sensitivity and early antiretroviral therapy mortality

Abstract Background In 2012, as a pilot for Botswana’s national Xpert MTB/RIF (Xpert) rollout plans, intensified tuberculosis (TB) case finding (ICF) activities were strengthened at 22 HIV treatment clinics prior to phased activation of 13 Xpert instruments. Together, the strengthened ICF interventi...

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Bibliographic Details
Main Authors: Andrew F. Auld, Tefera Agizew, Sherri Pals, Alyssa Finlay, Ndwapi Ndwapi, Rosanna Boyd, Heather Alexander, Anikie Mathoma, Joyce Basotli, Sambayawo Gwebe-Nyirenda, James Shepherd, Tedd V. Ellerbrock, Anand Date
Format: Article
Language:English
Published: BMC 2016-10-01
Series:BMC Infectious Diseases
Subjects:
Xpert MTB/RIF
Diagnostic accuracy
Sensitivity
Antiretroviral therapy
People living with HIV
Mortality
Online Access:http://link.springer.com/article/10.1186/s12879-016-1905-4

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http://link.springer.com/article/10.1186/s12879-016-1905-4

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