Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis

Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis

CREB-regulated transcription coactivator 2, CRTC2, has been associated with regulation of glucose and lipid homeostasis. Here Han et al. show that Creb/Crtc2 modulates lipid and glucose metabolism by inhibiting the expression of mi-R34 that, in turn, represses the expression of Sirt1 and PPARα and c...

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Main Authors: Hye-Sook Han, Byeong Hun Choi, Jun Seok Kim, Geon Kang, Seung-Hoi Koo
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01878-6
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spelling doaj-95fe6a39c576491889a4a394d3aca70c2021-05-11T07:14:52ZengNature Publishing GroupNature Communications2041-17232017-11-018111010.1038/s41467-017-01878-6Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axisHye-Sook Han0Byeong Hun Choi1Jun Seok Kim2Geon Kang3Seung-Hoi Koo4Division of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityCREB-regulated transcription coactivator 2, CRTC2, has been associated with regulation of glucose and lipid homeostasis. Here Han et al. show that Creb/Crtc2 modulates lipid and glucose metabolism by inhibiting the expression of mi-R34 that, in turn, represses the expression of Sirt1 and PPARα and consequently Fgf21 levels.https://doi.org/10.1038/s41467-017-01878-6
collection DOAJ
language English
format Article
sources DOAJ
author Hye-Sook Han
Byeong Hun Choi
Jun Seok Kim
Geon Kang
Seung-Hoi Koo
spellingShingle Hye-Sook Han
Byeong Hun Choi
Jun Seok Kim
Geon Kang
Seung-Hoi Koo
Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
Nature Communications
author_facet Hye-Sook Han
Byeong Hun Choi
Jun Seok Kim
Geon Kang
Seung-Hoi Koo
author_sort Hye-Sook Han
title Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_short Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_full Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_fullStr Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_full_unstemmed Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_sort hepatic crtc2 controls whole body energy metabolism via a mir-34a-fgf21 axis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description CREB-regulated transcription coactivator 2, CRTC2, has been associated with regulation of glucose and lipid homeostasis. Here Han et al. show that Creb/Crtc2 modulates lipid and glucose metabolism by inhibiting the expression of mi-R34 that, in turn, represses the expression of Sirt1 and PPARα and consequently Fgf21 levels.
url https://doi.org/10.1038/s41467-017-01878-6
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AT byeonghunchoi hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis
AT junseokkim hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis
AT geonkang hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis
AT seunghoikoo hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis
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