Cytoplasm-translocated Ku70/80 complex sensing of HBV DNA induces hepatitis-associated chemokine secretion

Cytoplasm-translocated Ku70/80 complex sensing of HBV DNA induces hepatitis-associated chemokine secretion

Chronic hepatitis B remains a serious disease, mainly owing to the severe pathological consequences of persistent hepatitis B virus (HBV) infection of carriers, which is difficult to cure using current therapies. When the immune system responds to hepatocytes experiencing rapid HBV replication, effe...

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Bibliographic Details
Main Authors: Haiming Wei, Young Li, Yang Wu, Xiaohu Zheng, Jingjing Cong, Yanyan Liu, Jiabin Li, Rui Sun, Zhigang Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
chemokine
innate immunity
HBV
DNA sensor
IRF1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00569/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00569/full

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