Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza.

Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza.

New prophylactic and therapeutic strategies to combat human infections with highly pathogenic avian influenza (HPAI) H5N1 viruses are needed. We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of infection.Us...

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Bibliographic Details
Main Authors: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan, Kimberly Mills, Jerrold M Ward, Nguyen Van Vinh Chau, Tran Tinh Hien, Federica Sallusto, Do Quang Ha, Jeremy Farrar, Menno D de Jong, Antonio Lanzavecchia, Kanta Subbarao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-05-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1880850?pdf=render

Internet

http://europepmc.org/articles/PMC1880850?pdf=render

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