Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture

Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture

Abstract Background Hypermethylation of gene promoters has been regarded as an epigenetic regulator for gene inactivation in the development of several diseases. In the current study, we aimed to explore how long noncoding RNA X-inactive specific transcript (lncRNA XIST) function in collagen degrada...

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Bibliographic Details
Main Authors: Hongwei Chen, Shengdi Yang, Ruyi Shao
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Arthritis Research & Therapy
Subjects:
Long noncoding RNA XIST
TIMP-3
Methylation
Osteoarthritis
Chondrocytes
Collagen degradation
Online Access:https://doi.org/10.1186/s13075-019-2033-5

Internet

https://doi.org/10.1186/s13075-019-2033-5

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