Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study
Abstract Background: In the Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial (SHIFT), heart rate (HR) reduction with ivabradine was associated with improved survival and reduced hospitalizations in patients with heart failure (HF). The mechanisms by which elevated HR increase...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Cardiologia (SBC)
|
Series: | Arquivos Brasileiros de Cardiologia |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004400455&lng=en&tlng=en |
id |
doaj-96876de091194471aeb3b8d6f5a210c0 |
---|---|
record_format |
Article |
spelling |
doaj-96876de091194471aeb3b8d6f5a210c02020-11-25T00:24:01ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-4170107545545910.5935/abc.20160166S0066-782X2016004400455Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy StudyAline Sterque VillacortaHumberto Villacorta JuniorJenne Serrão de SouzaJosé Antônio Caldas TeixeiraMaria Clara S. S. S. MuradasChristiane Rodrigues AlvesBernardo Campanário PrechtPilar PortoLetícia UbaldoCláudio Tinoco MesquitaAntônio Cláudio Lucas da NóbregaAbstract Background: In the Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial (SHIFT), heart rate (HR) reduction with ivabradine was associated with improved survival and reduced hospitalizations in patients with heart failure (HF). The mechanisms by which elevated HR increases mortality are not fully understood. Objective: To assess the relationship of baseline HR with clinical, neurohormonal and cardiac sympathetic activity in patients with chronic HF and elevated HR. Method: Patients with chronic HF who were in sinus rhythm and had resting HR>70 bpm despite optimal medical treatment were included in a randomized, double-blind study comparing ivabradine versus pyridostigmine. This report refers to the baseline data of 16 initial patients. Baseline HR (before randomization to one of the drugs) was assessed, and patients were classified into two groups, with HR below or above mean values. Cardiac sympathetic activity was assessed by 123-iodine-metaiodobenzylguanidine myocardial scintigraphy. Results: Mean HR was 83.5±11.5 bpm (range 72 to 104), and seven (43.7%) patients had HR above the mean. These patients had lower 6-min walk distance (292.3±93 vs 465.2±97.1 m, p=0.0029), higher values of N-Terminal-proBNP (median 708.4 vs 76.1, p=0.035) and lower late heart/mediastinum rate, indicating cardiac denervation (1.48±0.12 vs 1.74±0.09, p<0.001). Conclusion: Elevated resting HR in patients with HF under optimal medical treatment was associated with cardiac denervation, worse functional capacity, and neurohormonal activation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004400455&lng=en&tlng=enFrequência CardíacaDenervaçãoInsuficiência CardíacaMiocárdio / cintilografiaSistema Nervoso Simpático |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aline Sterque Villacorta Humberto Villacorta Junior Jenne Serrão de Souza José Antônio Caldas Teixeira Maria Clara S. S. S. Muradas Christiane Rodrigues Alves Bernardo Campanário Precht Pilar Porto Letícia Ubaldo Cláudio Tinoco Mesquita Antônio Cláudio Lucas da Nóbrega |
spellingShingle |
Aline Sterque Villacorta Humberto Villacorta Junior Jenne Serrão de Souza José Antônio Caldas Teixeira Maria Clara S. S. S. Muradas Christiane Rodrigues Alves Bernardo Campanário Precht Pilar Porto Letícia Ubaldo Cláudio Tinoco Mesquita Antônio Cláudio Lucas da Nóbrega Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study Arquivos Brasileiros de Cardiologia Frequência Cardíaca Denervação Insuficiência Cardíaca Miocárdio / cintilografia Sistema Nervoso Simpático |
author_facet |
Aline Sterque Villacorta Humberto Villacorta Junior Jenne Serrão de Souza José Antônio Caldas Teixeira Maria Clara S. S. S. Muradas Christiane Rodrigues Alves Bernardo Campanário Precht Pilar Porto Letícia Ubaldo Cláudio Tinoco Mesquita Antônio Cláudio Lucas da Nóbrega |
author_sort |
Aline Sterque Villacorta |
title |
Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study |
title_short |
Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study |
title_full |
Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study |
title_fullStr |
Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study |
title_full_unstemmed |
Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study |
title_sort |
elevated heart rate is associated with cardiac denervation in patients with heart failure: a 123-iodine-mibg myocardial scintigraphy study |
publisher |
Sociedade Brasileira de Cardiologia (SBC) |
series |
Arquivos Brasileiros de Cardiologia |
issn |
1678-4170 |
description |
Abstract Background: In the Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial (SHIFT), heart rate (HR) reduction with ivabradine was associated with improved survival and reduced hospitalizations in patients with heart failure (HF). The mechanisms by which elevated HR increases mortality are not fully understood. Objective: To assess the relationship of baseline HR with clinical, neurohormonal and cardiac sympathetic activity in patients with chronic HF and elevated HR. Method: Patients with chronic HF who were in sinus rhythm and had resting HR>70 bpm despite optimal medical treatment were included in a randomized, double-blind study comparing ivabradine versus pyridostigmine. This report refers to the baseline data of 16 initial patients. Baseline HR (before randomization to one of the drugs) was assessed, and patients were classified into two groups, with HR below or above mean values. Cardiac sympathetic activity was assessed by 123-iodine-metaiodobenzylguanidine myocardial scintigraphy. Results: Mean HR was 83.5±11.5 bpm (range 72 to 104), and seven (43.7%) patients had HR above the mean. These patients had lower 6-min walk distance (292.3±93 vs 465.2±97.1 m, p=0.0029), higher values of N-Terminal-proBNP (median 708.4 vs 76.1, p=0.035) and lower late heart/mediastinum rate, indicating cardiac denervation (1.48±0.12 vs 1.74±0.09, p<0.001). Conclusion: Elevated resting HR in patients with HF under optimal medical treatment was associated with cardiac denervation, worse functional capacity, and neurohormonal activation. |
topic |
Frequência Cardíaca Denervação Insuficiência Cardíaca Miocárdio / cintilografia Sistema Nervoso Simpático |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004400455&lng=en&tlng=en |
work_keys_str_mv |
AT alinesterquevillacorta elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT humbertovillacortajunior elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT jenneserraodesouza elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT joseantoniocaldasteixeira elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT mariaclarasssmuradas elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT christianerodriguesalves elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT bernardocampanarioprecht elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT pilarporto elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT leticiaubaldo elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT claudiotinocomesquita elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy AT antonioclaudiolucasdanobrega elevatedheartrateisassociatedwithcardiacdenervationinpatientswithheartfailurea123iodinemibgmyocardialscintigraphystudy |
_version_ |
1725354396591587328 |