The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB<sub>1</sub> Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations

The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB<sub>1</sub> Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations

Recreational use of synthetic cannabinoids (SCs) before and during pregnancy poses a major public health risk, due to the potential onset of neurodevelopmental disorders in the offspring. Herein, we report the assessment of the neurotoxic potential of two commonly abused SCs, THJ-2201 and 5F-PB22, p...

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Bibliographic Details
Main Authors: João Alexandre, Rui Malheiro, Diana Dias da Silva, Helena Carmo, Félix Carvalho, João Pedro Silva
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
developmental neurotoxicity
endocannabinoid system
neurogenesis
new psychoactive substances
substances of abuse
Online Access:https://www.mdpi.com/1422-0067/21/17/6277

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https://www.mdpi.com/1422-0067/21/17/6277

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