Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling

Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling

Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecula...

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Bibliographic Details
Main Authors: Anne Müller, Lars Niederstadt, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Endocrinology
Subjects:
Inflammation
G protein coupled receptor
protein network
weight regulation
Protein complementation assay
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00109/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00109/full

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