Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis

Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis

Microglia are the brain's immune cells and play an important role in regulating the microenvironment in the central nervous system. Activated microglia are capable of acquiring the pro-inflammatory (M1) phenotype and anti-inflammatory (M2) phenotype. Overactivation of microglia is neurotoxic an...

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Bibliographic Details
Main Authors: Bingrun Liu, Bingxu Huang, Guiqiu Hu, Dewei He, Yuhang Li, Xin Ran, Jian Du, Shoupeng Fu, Dianfeng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
isovitexin
microglia polarization
neuroinflammation
microglial markers
M1/M2 microglia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02650/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02650/full

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