A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer

Abstract Background Mismatch repair (MMR)/microsatellite instability (MSI) and tumor mutational burden (TMB) are independent biomarkers that complement each other for predicting immune checkpoint inhibitors (ICIs) efficacy. Here we aim to establish a strategy that integrates MSI and TMB determinatio...

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Main Authors: Jian Xiao, Wenyun Li, Yan Huang, Mengli Huang, Shanshan Li, Xiaohui Zhai, Jing Zhao, Chan Gao, Wenzhuan Xie, Hao Qin, Shangli Cai, Yuezong Bai, Ping Lan, Yifeng Zou
Format: Article
Published: BMC 2021-03-01
Series:BMC Cancer
Online Access:https://doi.org/10.1186/s12885-021-07942-1