Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties

Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor, playing key roles in maintenance of adipose tissue and in regulation of glucose and lipid homeostasis. This receptor is the target of thiazolidi...

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Bibliographic Details
Main Authors: Helder Veras Ribeiro Filho, Natália Bernardi Videira, Aline Villanova Bridi, Thais Helena Tittanegro, Fernanda Aparecida Helena Batista, José Geraldo de Carvalho Pereira, Paulo Sérgio Lopes de Oliveira, Marcio Chaim Bajgelman, Albane Le Maire, Ana Carolina Migliorini Figueira
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Endocrinology
Subjects:
peroxisome proliferator activator receptor γ
diabetes
adipogenesis
ligand screening pipeline
non-agonist
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00011/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2018.00011/full

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