Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study
Background/purpose: This study assessed the quality of life (QoL) and pregnancy outcomes among infertile women undergoing in vitro fertilization (IVF) treatment to investigate the association between QoL and IVF pregnancy outcomes. Methods: This study included 686 women with 1205 embryo transfers (E...
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doaj-9828fa3a38ae4ecca326bbd9cbef0ec52020-11-24T22:09:11ZengElsevierJournal of the Formosan Medical Association0929-66462020-01-011191471479Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort studyMeng-Hsing Wu0Pei-Fang Su1Wei-Ying Chu2New Geok Huey3Chih-Wei Lin4Huang-Tz Ou5Chung-Ying Lin6Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Statistics, National Cheng Kung University, Tainan, TaiwanDepartment of Statistics, National Cheng Kung University, Tainan, TaiwanDepartment of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInstitute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan; Corresponding author. 1 University Road, Tainan 7010, Taiwan. Fax: +886 6 2373149.Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong KongBackground/purpose: This study assessed the quality of life (QoL) and pregnancy outcomes among infertile women undergoing in vitro fertilization (IVF) treatment to investigate the association between QoL and IVF pregnancy outcomes. Methods: This study included 686 women with 1205 embryo transfers (ETs). QoL was measured using the fertility quality of life (FertiQoL) tool before ET. FertiQoL comprises two modules: a Core module (including mind/body, emotional, relational, and social domains) and a Treatment module (covering treatment environment and tolerability domains). The FertiQol total and subscale scores were computed and scored in the range of 0–100 (higher scores indicate better QoL). Multivariate generalized estimating equation analyses were carried out to assess the association between QoL and IVF pregnancy outcomes, with adjustment for time-varying factors across multiple ETs for a given person. Results: The lowest score in the core module was for the emotional domain (62.0), and that in the Treatment module was for the tolerability domain (59.4). QoL scores were significantly and positively associated with pregnancy outcomes (i.e., ongoing pregnancy, live birth); with a one unit increase in the emotional domain score, the probabilities of ongoing pregnancy and live birth significantly increased by 2.4% and 2.6%, respectively (p < 0.05). Conclusion: This study evaluated the prospective association between QoL and IVF pregnancy outcomes among infertile women. The results highlight the importance of developing clinical strategies to improve QoL among infertile women undergoing IVF treatment, which may further improve the pregnancy rates of this population. Keywords: In vitro fertilization, Quality of life, FertiQoL, Pregnancyhttp://www.sciencedirect.com/science/article/pii/S0929664618307885 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meng-Hsing Wu Pei-Fang Su Wei-Ying Chu New Geok Huey Chih-Wei Lin Huang-Tz Ou Chung-Ying Lin |
spellingShingle |
Meng-Hsing Wu Pei-Fang Su Wei-Ying Chu New Geok Huey Chih-Wei Lin Huang-Tz Ou Chung-Ying Lin Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study Journal of the Formosan Medical Association |
author_facet |
Meng-Hsing Wu Pei-Fang Su Wei-Ying Chu New Geok Huey Chih-Wei Lin Huang-Tz Ou Chung-Ying Lin |
author_sort |
Meng-Hsing Wu |
title |
Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study |
title_short |
Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study |
title_full |
Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study |
title_fullStr |
Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study |
title_full_unstemmed |
Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study |
title_sort |
quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: a longitudinal cohort study |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2020-01-01 |
description |
Background/purpose: This study assessed the quality of life (QoL) and pregnancy outcomes among infertile women undergoing in vitro fertilization (IVF) treatment to investigate the association between QoL and IVF pregnancy outcomes. Methods: This study included 686 women with 1205 embryo transfers (ETs). QoL was measured using the fertility quality of life (FertiQoL) tool before ET. FertiQoL comprises two modules: a Core module (including mind/body, emotional, relational, and social domains) and a Treatment module (covering treatment environment and tolerability domains). The FertiQol total and subscale scores were computed and scored in the range of 0–100 (higher scores indicate better QoL). Multivariate generalized estimating equation analyses were carried out to assess the association between QoL and IVF pregnancy outcomes, with adjustment for time-varying factors across multiple ETs for a given person. Results: The lowest score in the core module was for the emotional domain (62.0), and that in the Treatment module was for the tolerability domain (59.4). QoL scores were significantly and positively associated with pregnancy outcomes (i.e., ongoing pregnancy, live birth); with a one unit increase in the emotional domain score, the probabilities of ongoing pregnancy and live birth significantly increased by 2.4% and 2.6%, respectively (p < 0.05). Conclusion: This study evaluated the prospective association between QoL and IVF pregnancy outcomes among infertile women. The results highlight the importance of developing clinical strategies to improve QoL among infertile women undergoing IVF treatment, which may further improve the pregnancy rates of this population. Keywords: In vitro fertilization, Quality of life, FertiQoL, Pregnancy |
url |
http://www.sciencedirect.com/science/article/pii/S0929664618307885 |
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