Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions. TAAR1 is stimulated with nanomolar affinity by 3-iodothyronamine (...

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Bibliographic Details
Main Authors: Grazia Rutigliano, Julia Bräunig, Claudia Del Grande, Vittoria Carnicelli, Isabella Masci, Sergio Merlino, Gunnar Kleinau, Luca Tessieri, Simone Pardossi, Sarah Paisdzior, Liliana Dell’Osso, Heike Biebermann, Riccardo Zucchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
trace amine associated receptor 1
major mental disorders
single-nucleotide variants
3-iodothyronamine
Gs/adenylyl cyclase activation
tridimensional homology model
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01027/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01027/full

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