Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-b...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/22510 |