Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

Summary: Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer’s disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amy...

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Bibliographic Details
Main Authors: Goonho Park, Hoang S. Nhan, Sheue-Houy Tyan, Yusuke Kawakatsu, Carolyn Zhang, Mario Navarro, Edward H. Koo
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
APP
caspase
APP C31
synaptic injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308202

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http://www.sciencedirect.com/science/article/pii/S2211124720308202

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