A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma
Yang Yu,* Xiao Feng,* Shundong Cang Department of Oncology, Henan Province People’s Hospital, Henan University, Zhengzhou, Henan, China *These authors contributed equally to this work Background and aim: Some cancer-specific miRNAs are dysregulated in pancreatic adenocarcinoma (PAAD) and i...
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doaj-9976aa9fc23348b6840f5cc8a29572c52020-11-25T00:11:38ZengDove Medical PressCancer Management and Research1179-13222018-06-01Volume 101507151538800A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinomaYu YFeng XCang SYang Yu,* Xiao Feng,* Shundong Cang Department of Oncology, Henan Province People’s Hospital, Henan University, Zhengzhou, Henan, China *These authors contributed equally to this work Background and aim: Some cancer-specific miRNAs are dysregulated in pancreatic adenocarcinoma (PAAD) and involved in cell autophagy, differentiation, proliferation, migration, invasion, and malignant transformation. The aim of our study was to determine a panel of new diagnostic and prognostic biomarkers for PAAD. Methods: We conducted a comprehensive analysis of global miRNA-expression profiles and corresponding prognosis information of 168 PAAD patients from the Cancer Genome Atlas data set. A total of 16 differentially expressed miRNAs were identified as aberrantly expressed in PAAD, and six of these were evaluated for use as diagnostic markers for PAAD. Next, we confirmed a two-miRNA signature significantly associated with PAAD patient diagnosis and outcome prediction. Results: The panel of two miRNAs showed outstanding diagnostic performance, with sensitivity of 100% and specificity of 87.5%. Finally, we divided the PAAD patients into high-risk and low-risk groups based on the expression profile of the two miRNAs. Kaplan–Meier analysis demonstrated that patients in the high-risk group had significantly worse prognosis than patients in the low-risk group. Univariate and multivariate Cox regression analysis showed that the two-miRNA signature was an independent prognostic factor for the overall survival of PAAD patients. Conclusion: Taken together, the two-miRNA signature may serve as an accurate and sensitive biomarker for diagnosis and PAAD-outcome prediction, facilitating the diagnosis and potentially improving treatment outcome of PAAD. Keywords: pancreatic adenocarcinoma, microRNA signature, TCGA, prognosis, diagnosishttps://www.dovepress.com/a-two-microrna-signature-as-a-diagnostic-and-prognostic-marker-of-panc-peer-reviewed-article-CMARPancreatic adenocarcinomamicroRNA signatureTCGAprognosisdiagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Y Feng X Cang S |
spellingShingle |
Yu Y Feng X Cang S A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma Cancer Management and Research Pancreatic adenocarcinoma microRNA signature TCGA prognosis diagnosis |
author_facet |
Yu Y Feng X Cang S |
author_sort |
Yu Y |
title |
A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_short |
A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_full |
A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_fullStr |
A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_full_unstemmed |
A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_sort |
two-microrna signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2018-06-01 |
description |
Yang Yu,* Xiao Feng,* Shundong Cang Department of Oncology, Henan Province People’s Hospital, Henan University, Zhengzhou, Henan, China *These authors contributed equally to this work Background and aim: Some cancer-specific miRNAs are dysregulated in pancreatic adenocarcinoma (PAAD) and involved in cell autophagy, differentiation, proliferation, migration, invasion, and malignant transformation. The aim of our study was to determine a panel of new diagnostic and prognostic biomarkers for PAAD. Methods: We conducted a comprehensive analysis of global miRNA-expression profiles and corresponding prognosis information of 168 PAAD patients from the Cancer Genome Atlas data set. A total of 16 differentially expressed miRNAs were identified as aberrantly expressed in PAAD, and six of these were evaluated for use as diagnostic markers for PAAD. Next, we confirmed a two-miRNA signature significantly associated with PAAD patient diagnosis and outcome prediction. Results: The panel of two miRNAs showed outstanding diagnostic performance, with sensitivity of 100% and specificity of 87.5%. Finally, we divided the PAAD patients into high-risk and low-risk groups based on the expression profile of the two miRNAs. Kaplan–Meier analysis demonstrated that patients in the high-risk group had significantly worse prognosis than patients in the low-risk group. Univariate and multivariate Cox regression analysis showed that the two-miRNA signature was an independent prognostic factor for the overall survival of PAAD patients. Conclusion: Taken together, the two-miRNA signature may serve as an accurate and sensitive biomarker for diagnosis and PAAD-outcome prediction, facilitating the diagnosis and potentially improving treatment outcome of PAAD. Keywords: pancreatic adenocarcinoma, microRNA signature, TCGA, prognosis, diagnosis |
topic |
Pancreatic adenocarcinoma microRNA signature TCGA prognosis diagnosis |
url |
https://www.dovepress.com/a-two-microrna-signature-as-a-diagnostic-and-prognostic-marker-of-panc-peer-reviewed-article-CMAR |
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