Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

Abstract Background The serine protease HtrA is an important factor for regulating stress responses and protein quality control in bacteria. In recent studies, we have demonstrated that the gastric pathogen Helicobacter pylori can secrete HtrA into the extracellular environment, where it cleaves-off...

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Bibliographic Details
Main Authors: Aileen Harrer, Manja Boehm, Steffen Backert, Nicole Tegtmeyer
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Gut Pathogens
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13099-017-0189-6